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reparative cells, the use of scaffolds (designed to provide a structural and logistic template for tissue development and to biodegrade at a controlled rate), and bioreactors (designed to control cellular microenvironment, facilitate mass transport to and from the cells, and provide the necessary biochemical and physical regulatory signals). Many different tissues have been engineered by utilizing variations of the biomimetic approach depicted in Fig. 6.2. In each case, the material properties of the native tissue provide the basis for establishing tissue engineering requirements and standards of success. We will describe the components of this model system by referring to cartilage and myocardium, which perform structural and mechanical functions vital for health and survival and are of high clinical interest because of their inability for self-repair and distinctly different in many respects. Articular cartilage is an avascular tissue containing only one cell type, the chondrocyte, at a very low concentration. Chondrocytes maintain an extracellular matrix (ECM) consisting of a brous network of collagen type II and glycosaminoglycan (GAG)-rich proteoglycan [Buckwalter and Mankin, 1997]. Cartilage covers the surfaces of our joints, and its main function is to transfer compressive and shear forces during joint loading. The myocardium (cardiac muscle) is a highly vascularized muscular organ composed of cardiac myocytes, broblasts, and macrophages present at very high

THE PERCEPTUAL PROBLEM We must begin our discussion with some philosophical considerations. This is not merely because all of science began as philosophy, nor because only 50 years ago philosophy and psychology departments were often combined as the same academic entity in many universities. The reason that we begin with philosophy is that one must rst understand that it takes a shift in philosophical viewpoint, away from our normal naive realistic faith in the ability of our senses to convey a picture of the world to us, for the very basic question of why we need a psychological discipline to study sensation and

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TABLE 3.24 More Precise Regression Results (Almost Perfect)

In no case may we interpret an action as the outcome of the exercise of a higher psychical faculty, if it can be interpreted as the outcome of the exercise of one which stands lower in the psychological scale. (p. 53)

Possibilities and Problems of Multipage Sites The Pros of multipage sites for your visitors The Cons of multipage sites for your visitors The Pros of developing a multipage site The Cons of developing a multipage site Dividing the Site By origination of content By type of content By visitor type Dividing Content Site Architecture Linear architecture: The forced march Hierarchical architecture Avoid extreme devotion to hierarchy Anarchy A seamless web 411 412 412 414 414 414 415 416 417 419 421 422 423 423 424 424.

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The error polynomial is then e(X ) = 6 X 2 + 4 X 4 so that the received vector is corrected by adding to it the error pattern, and thus the decoded vector is nally the all-zero vector.

In the wireline Internet, improving the scalability of backbone and origin servers is of prime concern. In the mobile Internet, however, air interface is usually the bottleneck of end-to-end performance and user experience. Consequently, existing wireline content delivery techniques, which use edge caching to minimize the backbone usage, are not effective in the mobile Internet. Mobile content delivery techniques must be able to optimize content transmission over the radio link in order to enhance the mobile user experience. These techniques will work in unison with the techniques described in Section 6.2.1 to improve the end-to-end performance. Because many existing wireline Web applications are expected to run on the mobile terminals too, it is critical for mobile content delivery techniques to minimize the changes that applications need to make. For this reason, the split proxy architecture shown in Figure 6.5 is favored in many scenarios [31,33]. The network proxy, typically deployed in the radio access network, communicates with the client proxy using protocols optimized for the radio link, providing a transparent communications interface to applications running on the client and the server. This architecture has been adopted by systems such as the Wireless Application Protocol (WAP) [35]. The architecture that we will discuss later in the chapter, ACME, can also be viewed as a avor of the split-proxy approach. 6.2.3 Related Work

Another time-saving mechanism is the MT::Request package. MT::Request provides a place to store data that lives for the duration of the active HTTP request. The following example demonstrates how you might cache lookups for some data into the MT::Request object: